Performance Evaluation of CBC Analysis on miLab™ BCM: A Comparative Study with Sysmex XN Hematology Analyzer

The miLab™ BCM is a clinically viable, AI-assisted point-of-care solution that delivers reliable CBC and 6-part differential results from just 5 µL of blood, streamlining workflow for diverse clinical settings, including neonates.

ISLH 2026

April 18, 2026

CY Bae, et al.

Performance Evaluation of CBC Analysis on miLab™ BCM: A Comparative Study with Sysmex XN Hematology Analyzer

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Abstract

Analyzing 102 whole blood samples, including neonatal specimens, the miLab™ BCM, utilizing a 5 µL sample for its automated CBC and 6-part differential workflow, demonstrated strong analytical correlation and agreement with the Sysmex XN-series (e.g., WBC R=0.981, IG R=0.852), confirming its high utility as a reliable, clinically viable point-of-care solution.

	N	Correlation coefficient (R)	Slope (95% CI)	Intercept (95% CI)	Mean bias (LLoA, ULoA)
WBC (10³/µL)	102	0.981	0.989 (0.927, 1.052)	0.305 (-0.033, 0.694)	0.443 (-12.722, 13.608)
RBC (10⁶/µL)	102	0.956	0.948 (0.897, 1.019)	0.246 (-0.012, 0.462)	0.045 (-0.567, 0.657)
PLT (10³/µL)	102	0.979	0.925 (0.883, 0.969)	5.274 (-0.651, 10.288)	-13.039 (-86.405, 60.326)
HGB (g/dL)	102	0.959	0.980 (0.920, 1.050)	0.439 (-0.216, 1.134)	0.210 (-1.579, 1.999)
HCT (%)	102	0.955	0.989 (0.947, 1.042)	0.521 (-1.149, 2.027)	0.027 (-5.528, 5.582)
RDW-CV (%)	90	0.819	0.712 (0.596, 0.827)	4.081 (2.353, 5.637)	-0.444 (-3.394, 2.505)
Neutrophil %	97	0.926	1.015 (0.970, 1.091)	0.249 (-2.192, 4.079)	1.270 (-17.166, 19.706)
Lymphocyte %	97	0.857	0.996 (0.949, 1.056)	-1.901 (-3.667, -0.235)	0.171 (-23.821, 24.162)
Monocyte %	97	0.771	0.946 (0.815, 1.103)	-0.926 (-2.267, 0.033)	-3.519 (-26.559, 19.522)
Eosinophil %	97	0.911	0.951 (0.784, 1.066)	-0.007 (-0.106, 0.000)	-0.200 (-2.690, 2.290)
Basophil %	97	0.700	3.069 (-8.404, 14.542)	-0.614 (-4.877, 3.650)	0.263 (-1.880, 2.406)
IG %	97	0.852	0.876 (0.642, 1.111)	-0.763 (-1.275, -0.252)	-1.155 (-7.168, 4.858)

Table 1. Method Comparison and Bias Analysis of the miLab™ BCM vs. Sysmex XN-series (N=102)

Key Highlights

The miLab™ BCM showed strong correlation with the Sysmex XN for CBC and 6-part differential parameters.
Reliable results were confirmed for diverse patient cohorts, especially neonatal specimens.
It could be a practical point-of-care solution requiring only 5 µL of whole blood for neonatal specimens.
The analyzer streamlines workflow with AI-assisted digital imaging and a 'single-run' process.

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